I use organic sprays at times in the vegetables.
The vine borers have not arrived here, as best as I know. There are no fire ants but when an ant colony is somewhere that I don't want it, "messing it up" thoroughly with a sparing fork has been enuf for them to move. I do have to pay attention to that area so that the new ant hill isn't just built in another unacceptable location.
Squash bugs, cucumber beetles and stink bugs can be a problem. And yes, when they are, a one/two punch is sometimes needed. These bugs hide and squash leaves give them a good chance to avoid contact sprays. Organic sprays are not persistent so if they aren't killed immediately, those bugs will continue to make trouble.
Spinosad kills beetles but it has to be ingested within a few days. Pyrethrum can kill them if it is inhaled within hours. Spraying first the Spinosad and then the Pyrethrum a few days later really has worked well in my garden. Sometimes, I haven't felt that it was necessary to follow up with the Pyrethrum.
Steve